Product Description: mitochondrial import inner membrane translocase subunit TIM8, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0042719 | mitochondrial intermembrane space protein transporter complex |
| Process | GO:0045039 | protein insertion into mitochondrial inner membrane |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.04 | 0.98 |
| Trophozoite | possibly expressed | 0.11 | 0.93 |
| Schizont | not expressed | 0.01 | 0.99 |
| Gametocyte | not expressed | 0.07 | 0.96 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1421500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.953 | MFS: -1.697 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILN5
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101956
Most Similar Human Ortholog: Q9Y5J9
TM-align score: 0.85 | RMSD: 1.66
Seq Identity: 0.18 | Length: 82 / 113
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000126953 | translocase of inner mitochondrial membrane 8A |
| ENSG00000150779 | translocase of inner mitochondrial membrane 8 homolog B |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 3 | 0 | 5 |
| disruptive | 1 | 7 | 5 | 18 |
| missense | 0 | 7 | 5 | 18 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 4 | 6 | 7 |
| disruptive | 1 | 25 | 12 | 22 |
| missense | 0 | 23 | 10 | 18 |
PlasmoDB Total SNPs: 48
Non-coding: 46 | Synonymous: 1 | Nonsynonymous: 0 | Stop Codon: 1
Protein Length: 113 | Molecular Weight (kDa): 13.317
UniProt ID(s): Q8ILN5
PDB ID(s): None
Isoelectric Point: 7.47
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR004217 | Tim10-like |
| InterPro | IPR035427 | Tim10-like domain superfamily |
| InterPro | IPR039238 | Mitochondrial import inner membrane translocase subunit Tim8/13 |
| PFam | PF02953 | Tim10-like |
| Superfamily | SSF144122 | Tim10-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 29925672 | Divergent Small Tim Homologues Are Associated with TbTim17 and Critical for theBiogenesis of TbTim17 Protein Complexes in Trypanosoma brucei | Smith JT Jr, Singha UK, Misra S, Chaudhuri M | 10.1128/mSphere.00204-18 |
| 12923659 | Transcription of TIM9, a new factor required for the petite-positive phenotype ofSaccharomyces cerevisiae, is defective in spt7 mutants | Senapin S, Chen XJ, Clark-Walker GD | 10.1007/s00294-003-0437-9 |