PF3D7_1421600

Genome location: Pf3D7_14_v3:885,211..888,459(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005634	nucleus
Function	GO:0019784	NEDD8-specific protease activity
Function	GO:0004843	thiol-dependent deubiquitinase
Function	GO:0043130	ubiquitin binding
Process	GO:0071108	protein K48-linked deubiquitination

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.21	0.90
Trophozoite	expressed	0.38	0.77
Schizont	possibly expressed	0.05	0.97
Gametocyte	not expressed	0.35	0.80

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1421600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.259 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILN4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533472

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	5	33	25	42
disruptive	18	84	44	139
missense	13	69	33	110

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	11	75	25	53
disruptive	48	213	114	249
missense	27	154	90	148

PlasmoDB Total SNPs: 209

Non-coding: 140 | Synonymous: 49 | Nonsynonymous: 20 | Stop Codon: 0

Protein Information

Protein Length: 684 | Molecular Weight (kDa): 82.992

UniProt ID(s): Q8ILN4

PDB ID(s): None

Isoelectric Point: 7.45

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A