PF3D7_1421800

Genome location: Pf3D7_14_v3:888,580..890,032(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.07	0.95
Gametocyte	expressed	1.31	0.47

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1421800

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.203 | MFS: -2.671 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILN3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533348

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	17	13	21
disruptive	14	54	25	68
missense	11	36	17	50

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	36	19	26
disruptive	33	111	56	87
missense	18	71	42	61

PlasmoDB Total SNPs: 115

Non-coding: 47 | Synonymous: 40 | Nonsynonymous: 28 | Stop Codon: 0

Protein Information

Protein Length: 371 | Molecular Weight (kDa): 43.734

UniProt ID(s): Q8ILN3

PDB ID(s): None

Isoelectric Point: 8.74

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A