PF3D7_1421900 (CTR2)

Genome location: Pf3D7_14_v3:890,541..891,622(-)

Genome classification: Core

Function and Localization

Product Description: copper transporter, putative

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005886	plasma membrane
Function	GO:0005375	copper ion transmembrane transporter activity
Process	GO:0006878	cellular copper ion homeostasis

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	expressed	0.11	0.92
Schizont	expressed	0.23	0.83
Gametocyte	expressed	0.06	0.96

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1421900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.124 | MFS: -2.986 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1021500)

Modification: Disrupted | RMgm-1386

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILN2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_117238

Most Similar Human Ortholog: O15432

TM-align score: 0.66 | RMSD: 3.13

Seq Identity: 0.22 | Length: 116 / 160

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000136867	solute carrier family 31 member 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	3	4	14
disruptive	3	13	5	26
missense	3	13	3	23

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	11	10	17
disruptive	7	36	17	41
missense	3	32	13	32

PlasmoDB Total SNPs: 32

Non-coding: 21 | Synonymous: 9 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 160 | Molecular Weight (kDa): 18.752

UniProt ID(s): Q8ILN2, Q9NFF8

PDB ID(s): None

Isoelectric Point: 8.22

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR007274	Ctr copper transporter
PFam	PF04145	Ctr copper transporter
Superfamily	N/A	N/A