Product Description: cytochrome c oxidase assembly protein COX14, putative
SignalP Peptide: N/A
# Transmembrane Domains: 1
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | no data | N/A | N/A |
| Ring | no data | 0.03 | 0.99 |
| Trophozoite | no data | 0.25 | 0.84 |
| Schizont | no data | 0.23 | 0.84 |
| Gametocyte | no data | 0.32 | 0.81 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1422000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.132 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: C6S3H9
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 6 | 3 | 0 |
| disruptive | 1 | 3 | 1 | 7 |
| missense | 1 | 3 | 1 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 8 | 2 | 7 |
| disruptive | 2 | 7 | 6 | 22 |
| missense | 2 | 4 | 5 | 13 |
PlasmoDB Total SNPs: 110
Non-coding: 106 | Synonymous: 3 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 93 | Molecular Weight (kDa): 11.487
UniProt ID(s): C6S3H9
PDB ID(s): None
Isoelectric Point: 10.06
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR029208 | Cytochrome c oxidase assembly protein COX14 |
| PFam | PF14880 | Cytochrome c oxidase assembly protein COX14 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 19348890 | Chapter 11 Supercomplex organization of the yeast respiratory chain complexes andthe ADP/ATP carrier proteins | Stuart RA | 10.1016/S0076-6879(08)04411-X |
| 20807763 | The carboxyl-terminal end of Cox1 is required for feedback assembly regulation ofCox1 synthesis in Saccharomyces cerevisiae mitochondria | Shingu-Vazquez M, Camacho-Villasana Y, ..., Perez-Martinez X | 10.1074/jbc.M110.161976 |
| 26929411 | A Novel Function of Pet54 in Regulation of Cox1 Synthesis in Saccharomycescerevisiae Mitochondria | Mayorga JP, Camacho-Villasana Y, ..., Perez-Martinez X | 10.1074/jbc.M116.721985 |
| 30598554 | Structure of yeast cytochrome c oxidase in a supercomplex with cytochrome bc(1) | Hartley AM, Lukoyanova N, ..., Marechal A | 10.1038/s41594-018-0172-z |
| 21068384 | Cox25 teams up with Mss51, Ssc1, and Cox14 to regulate mitochondrial cytochrome coxidase subunit 1 expression and assembly in Saccharomyces cerevisiae | Fontanesi F, Clemente P, Barrientos A | 10.1074/jbc.M110.188805 |
| 35779633 | Overexpression of MRX9 impairs processing of RNAs encoding mitochondrialoxidative phosphorylation factors COB and COX1 in yeast | Chagas JAC, Kfouri Martins Soares MA, Ribeiro Franco LV, Barros MH | 10.1016/j.jbc.2022.102214 |
| 28490636 | The Cox1 C-terminal domain is a central regulator of cytochrome c oxidasebiogenesis in yeast mitochondria | Garcia-Villegas R, Camacho-Villasana Y, ..., Perez-Martinez X | 10.1074/jbc.M116.773077 |
| 19710419 | Dual functions of Mss51 couple synthesis of Cox1 to assembly of cytochrome coxidase in Saccharomyces cerevisiae mitochondria | Perez-Martinez X, Butler CA, Shingu-Vazquez M, Fox TD | 10.1091/mbc.e09-06-0522 |