Product Description: ribosomal protein L21, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.04 | 0.98 |
| Trophozoite | not expressed | 0.26 | 0.83 |
| Schizont | not expressed | 0.18 | 0.87 |
| Gametocyte | not expressed | 0.28 | 0.84 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1422100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.173 | MFS: -2.866 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_0703200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILN1
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101040
Most Similar Human Ortholog: Q7Z2W9
TM-align score: 0.59 | RMSD: 3.60
Seq Identity: 0.18 | Length: 147 / 380
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000197345 | mitochondrial ribosomal protein L21 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 18 | 6 | 29 |
| disruptive | 9 | 23 | 17 | 49 |
| missense | 4 | 18 | 16 | 36 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 40 | 14 | 33 |
| disruptive | 14 | 74 | 44 | 110 |
| missense | 6 | 54 | 32 | 74 |
PlasmoDB Total SNPs: 79
Non-coding: 67 | Synonymous: 7 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 380 | Molecular Weight (kDa): 45.581
UniProt ID(s): Q8ILN1
PDB ID(s): None
Isoelectric Point: 10.12
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR028909 | Ribosomal protein L21-like |
| InterPro | IPR036164 | L21-like superfamily |
| PFam | PF00829 | Ribosomal protein L21-like |
| Superfamily | SSF141091 | L21-like superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |