PF3D7_1422200

Genome location: Pf3D7_14_v3:895,874..897,254(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.02	0.99
Trophozoite	possibly expressed	0.04	0.97
Schizont	expressed	0.61	0.66
Gametocyte	expressed	0.52	0.71

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1422200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.121 | MFS: -2.925 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1021200)

Relative Growth Rate: 0.13 ± 0.05
Confidence: 7.26

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILN0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532559

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	13	7	22
disruptive	0	18	10	31
missense	0	18	10	25

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	25	18	26
disruptive	7	46	41	86
missense	4	36	30	64

PlasmoDB Total SNPs: 62

Non-coding: 49 | Synonymous: 9 | Nonsynonymous: 4 | Stop Codon: 0

Protein Information

Protein Length: 311 | Molecular Weight (kDa): 38.165

UniProt ID(s): Q8ILN0

PDB ID(s): None

Isoelectric Point: 9.49

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A