PF3D7_1422300

Genome location: Pf3D7_14_v3:897,267..899,556(-)

Genome classification: Core

Function and Localization

Product Description: DnaJ protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.26	0.87
Trophozoite	possibly expressed	0.41	0.76
Schizont	expressed	0.16	0.89
Gametocyte	expressed	0.85	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1422300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.168 | MFS: -3.269 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3I0

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532515

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	15	12	20
disruptive	10	36	22	55
missense	6	23	15	36

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	39	15	24
disruptive	31	101	55	115
missense	15	57	36	62

PlasmoDB Total SNPs: 193

Non-coding: 157 | Synonymous: 22 | Nonsynonymous: 14 | Stop Codon: 0

Protein Information

Protein Length: 354 | Molecular Weight (kDa): 42.591

UniProt ID(s): C6S3I0

PDB ID(s): None

Isoelectric Point: 10.13

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001623	DnaJ domain
InterPro	IPR018253	DnaJ domain, conserved site
InterPro	IPR036869	Chaperone J-domain superfamily
PFam	PF00226	DnaJ domain
Superfamily	SSF46565	Chaperone J-domain superfamily