PF3D7_1422400

Genome location: Pf3D7_14_v3:899,929..905,858(+)

Genome classification: Core

Function and Localization

Product Description: nucleolar RNA-associated protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0032545	CURI complex
Component	GO:0034456	UTP-C complex
Component	GO:0005730	nucleolus
Component	GO:0032040	small-subunit processome
Function	GO:0003723	RNA binding
Process	GO:0006364	rRNA processing
Process	GO:0006409	tRNA export from nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.75	0.65
Trophozoite	expressed	0.62	0.67
Schizont	expressed	0.28	0.83
Gametocyte	expressed	0.85	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1422400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.137 | MFS: -2.84 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1021000)

Relative Growth Rate: 0.07 ± 0.14
Confidence: 5.34

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILM9

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532620

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	19	79	44	83
disruptive	86	200	125	296
missense	51	169	108	266

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	27	158	54	112
disruptive	131	464	219	469
missense	71	368	185	327

PlasmoDB Total SNPs: 267

Non-coding: 52 | Synonymous: 93 | Nonsynonymous: 122 | Stop Codon: 0

Protein Information

Protein Length: 1630 | Molecular Weight (kDa): 195.366

UniProt ID(s): Q8ILM9

PDB ID(s): None

Isoelectric Point: 8.24

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005554	NOL6/Upt22
InterPro	IPR035368	Nrap protein, domain 3
InterPro	IPR035370	Nrap protein, domain 5
PFam	PF17404	Nrap protein, domain 3
PFam	PF17406	Nrap protein, domain 5
Superfamily	N/A	N/A