About Gene List

PF3D7_1422600

Genome location: Pf3D7_14_v3:910,212..912,272(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.04 0.98
Trophozoite not expressed 0.28 0.82
Schizont possibly expressed 0.31 0.79
Gametocyte not expressed 0.40 0.77

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1422600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.378 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILM7

"Best" AlphaFill ligand hit: PAM (palmitoleic acid, Local RMSD=2.98) with 6C0B (Global RMSD=16.00)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_114897

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 8 27 15 33
disruptive 27 75 30 91
missense 17 63 27 61

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 14 44 20 37
disruptive 48 156 73 177
missense 28 117 56 91

PlasmoDB Total SNPs: 72

Non-coding: 11 | Synonymous: 31 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 641 | Molecular Weight (kDa): 75.241

UniProt ID(s): Q8ILM7

PDB ID(s): None

Isoelectric Point: 7.94

Protein Domain Annotations:

Source Family ID Description
InterPro IPR016024 Armadillo-type fold
PFam N/A N/A
Superfamily SSF48371 Armadillo-type fold

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108