About Gene List

PF3D7_1422700

Genome location: Pf3D7_14_v3:913,234..917,625(+)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.34 0.84
Trophozoite not expressed 0.89 0.53
Schizont not expressed 0.27 0.83
Gametocyte not expressed 0.75 0.59

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1422700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.995 | MFS: -2.679 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1020700)

Modification: Disrupted | RMgm-2818

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILM6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532664

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 14 54 32 66
disruptive 79 194 75 214
missense 50 138 62 172

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 25 99 48 82
disruptive 136 337 131 303
missense 74 255 104 206

PlasmoDB Total SNPs: 216

Non-coding: 94 | Synonymous: 69 | Nonsynonymous: 53 | Stop Codon: 0

Protein Information

Protein Length: 1190 | Molecular Weight (kDa): 140.517

UniProt ID(s): Q8ILM6

PDB ID(s): None

Isoelectric Point: 5.64

Protein Domain Annotations:

Source Family ID Description
InterPro IPR003774 Protein of unknown function UPF0301
PFam PF02622 Protein of unknown function UPF0301
Superfamily SSF143456 N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108