PF3D7_1422900

Genome location: Pf3D7_14_v3:922,368..924,402(+)

Genome classification: Core

Function and Localization

Product Description: 14-3-3 protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	not expressed	0.06	0.97
Trophozoite	not expressed	0.03	0.98
Schizont	not expressed	0.03	0.98
Gametocyte	not expressed	0.39	0.79

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1422900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.556 | MFS: -0.262 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILM3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532865

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	17	13	30
disruptive	7	21	12	31
missense	7	20	12	27

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	3	38	22	34
disruptive	13	51	23	93
missense	8	39	19	67

PlasmoDB Total SNPs: 108

Non-coding: 78 | Synonymous: 23 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 425 | Molecular Weight (kDa): 50.842

UniProt ID(s): Q8ILM3

PDB ID(s): None

Isoelectric Point: 9.72

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR023410	14-3-3 domain
InterPro	IPR036815	14-3-3 domain superfamily
PFam	PF00244	14-3-3 domain
Superfamily	SSF48445	14-3-3 domain superfamily