Product Description: peptidyl-prolyl cis-trans isomerase
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 5.2.1.8 (Peptidylprolyl isomerase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0003755 | peptidyl-prolyl cis-trans isomerase activity |
| Process | GO:0006457 | protein folding |
| Process | GO:0000413 | protein peptidyl-prolyl isomerization |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.30 | 0.86 |
| Trophozoite | expressed | 0.61 | 0.66 |
| Schizont | expressed | 0.08 | 0.95 |
| Gametocyte | possibly expressed | 0.48 | 0.73 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1423200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.097 | #Insertions: 2
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1020200)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1020200)
Modification: Disrupted | RMgm-2814
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILM0
"Best" AlphaFill ligand hit: LSA (saccharin, Local RMSD=0.05) with 4N1O (Global RMSD=1.95)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 5.2.1.8 | peptidylprolyl isomerase | ATPNEMSDSPCMBFK506QAEGPKAla-ProjugloneSer-ProGPI-1046RNase T1Rapamycin... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102804
Most Similar Human Ortholog: D6REK3
TM-align score: 0.48 | RMSD: 2.58
Seq Identity: 0.40 | Length: 196 / 446
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000153015 | CWC27 spliceosome associated cyclophilin |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 19 | 12 | 21 |
| disruptive | 32 | 41 | 32 | 62 |
| missense | 13 | 27 | 23 | 46 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 34 | 18 | 26 |
| disruptive | 46 | 88 | 57 | 77 |
| missense | 16 | 54 | 47 | 58 |
PlasmoDB Total SNPs: 281
Non-coding: 220 | Synonymous: 31 | Nonsynonymous: 28 | Stop Codon: 2
Protein Length: 446 | Molecular Weight (kDa): 52.663
UniProt ID(s): Q8ILM0
PDB ID(s): None
Isoelectric Point: 7.52
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002130 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| InterPro | IPR029000 | Cyclophilin-like domain superfamily |
| PFam | PF00160 | Cyclophilin-type peptidyl-prolyl cis-trans isomerase domain |
| Superfamily | SSF50891 | Cyclophilin-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 22546550 | A family of cyclophilin-like molecular chaperones in Plasmodium falciparum. | Marin-Menendez A, Monaghan P, Bell A | 10.1016/j.molbiopara.2012.04.006 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 29621549 | Osh6p, a homologue of the oxysterol-binding protein, is involved in production offunctional cytochrome P450 belonging to CYP52 family in n-alkane-assimilatingyeast Yarrowia lipolytica | Iwama R, Hara M, ..., Fukuda R | 10.1016/j.bbrc.2018.04.002 |
| 23712643 | Removal of petroleum-crude oil from aqueous solution by Saccharomyces cerevisiaeSHSY strain necessitates at least an inducible CYP450ALK homolog gene | Hanano A, Al-Arfi M, ..., Shamma M | 10.1002/jobm.201200525 |
| 19054129 | Importance of the cytochrome P450 monooxygenase CYP52 family for thesophorolipid-producing yeast Candida bombicola | Van Bogaert IN, De Mey M, ..., Vandamme EJ | 10.1111/j.1567-1364.2008.00454.x |
| 15090141 | Development of a plant viral-vector-based gene expression assay for the screeningof yeast cytochrome p450 monooxygenases | Hanley K, Nguyen LV, ..., White EL | 10.1089/154065803321537863 |
| 31398949 | Taxonomic Distribution of Cytochrome P450 Monooxygenases (CYPs) among the BuddingYeasts (Sub-Phylum Saccharomycotina) | Linder T | 10.3390/microorganisms7080247 |
| 27039152 | Functional roles and substrate specificities of twelve cytochromes P450 belongingto CYP52 family in n-alkane assimilating yeast Yarrowia lipolytica | Iwama R, Kobayashi S, ..., Fukuda R | 10.1016/j.fgb.2016.03.007 |
| 32581293 | Phylogeny, evolution, and potential ecological relationship of cytochrome CYP52enzymes in Saccharomycetales yeasts | Ortiz-Alvarez J, Becerra-Bracho A, ..., Hernandez-Rodriguez C | 10.1038/s41598-020-67200-5 |