About Gene List

PF3D7_1423400

Genome location: Pf3D7_14_v3:941,899..947,048(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 4

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.07 0.97
Trophozoite not expressed 0.04 0.98
Schizont possibly expressed 0.24 0.85
Gametocyte expressed 0.76 0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1423400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -1.978 | #Insertions: 5

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILL8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533252

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 9 55 29 63
disruptive 57 155 89 240
missense 31 119 76 194

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 24 107 45 80
disruptive 109 365 207 415
missense 56 264 157 281

PlasmoDB Total SNPs: 238

Non-coding: 83 | Synonymous: 89 | Nonsynonymous: 66 | Stop Codon: 0

Protein Information

Protein Length: 1465 | Molecular Weight (kDa): 178.137

UniProt ID(s): Q8ILL8

PDB ID(s): None

Isoelectric Point: 9.48

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
12368868 Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. Gardner MJ, Shallom SJ, ..., Fraser CM 10.1038/nature01094