PF3D7_1423500

Genome location: Pf3D7_14_v3:947,041..952,924(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	expressed	N/A	N/A
Ring	expressed	0.32	0.89
Trophozoite	expressed	0.28	0.86
Schizont	expressed	0.77	0.62
Gametocyte	expressed	0.50	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1423500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 2 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.5 | #Insertions: 7

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILL7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_112919

Most Similar Human Ortholog: P07476

TM-align score: 0.29 | RMSD: 6.54

Seq Identity: 0.08 | Length: 244 / 1621

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000163207	involucrin

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	10	62	34	84
disruptive	87	183	110	241
missense	40	120	86	184

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	25	120	46	79
disruptive	149	436	179	403
missense	65	297	139	250

PlasmoDB Total SNPs: 415

Non-coding: 85 | Synonymous: 144 | Nonsynonymous: 186 | Stop Codon: 0

Protein Information

Protein Length: 1621 | Molecular Weight (kDa): 192.606

UniProt ID(s): Q8ILL7

PDB ID(s): None

Isoelectric Point: 10.27

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF141571	N/A