Product Description: 60S ribosomal protein L7-3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0022625 | cytosolic large ribosomal subunit |
| Component | GO:1903561 | extracellular vesicle |
| Component | GO:0005634 | nucleus |
| Function | GO:0003723 | RNA binding |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0000470 | maturation of LSU-rRNA |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 1.72 | 0.37 |
| Trophozoite | expressed | 2.18 | 0.19 |
| Schizont | expressed | 0.42 | 0.76 |
| Gametocyte | expressed | 0.99 | 0.51 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1424400
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.15 | MFS: -2.895 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILL2
"Best" AlphaFill ligand hit: GDP (guanosine-5'-diphosphate, Local RMSD=14.19) with 6ZHM (Global RMSD=16.37)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101259
Most Similar Human Ortholog: Q5T8U2
TM-align score: 0.90 | RMSD: 1.29
Seq Identity: 0.49 | Length: 144 / 283
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000148303 | ribosomal protein L7a |
| ENSG00000280858 | ribosomal protein L7a |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 1 | 0 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 129
Non-coding: 119 | Synonymous: 9 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 283 | Molecular Weight (kDa): 32.681
UniProt ID(s): Q8ILL2
PDB ID(s): 3J79, 3JBN, 3JBO, 3JBP, 5UMD
Isoelectric Point: 10.91
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001921 | Ribosomal protein L7A/L8 |
| InterPro | IPR004038 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| InterPro | IPR018492 | Ribosomal protein L7Ae/L8/Nhp2 family |
| InterPro | IPR029064 | 50S ribosomal protein L30e-like |
| PFam | PF01248 | Ribosomal protein L7Ae/L30e/S12e/Gadd45 |
| Superfamily | SSF55315 | 50S ribosomal protein L30e-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 28944300 | Proteomic analysis of extracellular vesicles from a Plasmodium falciparum Kenyanclinical isolate defines a core parasite secretome. | Abdi A, Yu L, ..., Rayner J | 10.12688/wellcomeopenres.11910.2 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 33906926 | Functional Characterization of the m(6)A-Dependent Translational Modulator PfYTH | Sinha A, Baumgarten S, ..., Scherf A | 10.1128/mBio.00661-21 |