Product Description: enoyl-CoA hydratase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 4.2.1.17 (Enoyl-CoA hydratase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005739 | mitochondrion |
| Function | GO:0004300 | enoyl-CoA hydratase activity |
| Process | GO:0006635 | fatty acid beta-oxidation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.24 | 0.84 |
| Schizont | expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.12 | 0.93 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1425200
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 1 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.245 | MFS: -3.354 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILL1
"Best" AlphaFill ligand hit: ACO (acetyl coenzyme *a, Local RMSD=0.83) with 1WDM (Global RMSD=2.60)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 4.2.1.17 | enoyl-CoA hydratase | CoANEMacetyl-CoAoctanoyl-CoAcrotonyl-CoAdecenoyl-CoAhexenoyl-CoAiodoacetamidepropionyl-CoApropanoyl-CoA3-octynoyl-CoAacetoacetyl-CoA... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102410
Most Similar Human Ortholog: Q86YB7
TM-align score: 0.82 | RMSD: 2.68
Seq Identity: 0.19 | Length: 265 / 406
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000121310 | enoyl-CoA hydratase domain containing 2 |
| ENSG00000148090 | AU RNA binding methylglutaconyl-CoA hydratase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 14 | 11 | 23 |
| disruptive | 3 | 17 | 18 | 45 |
| missense | 3 | 16 | 17 | 42 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 30 | 22 | 28 |
| disruptive | 12 | 60 | 38 | 90 |
| missense | 9 | 50 | 28 | 53 |
PlasmoDB Total SNPs: 151
Non-coding: 131 | Synonymous: 16 | Nonsynonymous: 4 | Stop Codon: 0
Protein Length: 406 | Molecular Weight (kDa): 48.259
UniProt ID(s): Q8ILL1
PDB ID(s): None
Isoelectric Point: 7.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001753 | Enoyl-CoA hydratase/isomerase |
| InterPro | IPR029045 | ClpP/crotonase-like domain superfamily |
| PFam | PF00378 | Enoyl-CoA hydratase/isomerase |
| Superfamily | SSF52096 | ClpP/crotonase-like domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |