About Gene List

PF3D7_1425300

Genome location: Pf3D7_14_v3:985,023..988,047(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.13 0.93
Trophozoite possibly expressed 0.38 0.77
Schizont expressed 0.99 0.49
Gametocyte possibly expressed 0.43 0.75

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1425300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.998 | MFS: -2.59 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A3H3

"Best" AlphaFill ligand hit: AN2 (amp phosphoramidate, Local RMSD=0.23) with 3IED (Global RMSD=29.92)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532444

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 5 12 5 20
disruptive 2 24 25 38
missense 2 22 23 35

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 6 26 8 21
disruptive 11 58 39 80
missense 6 45 34 57

PlasmoDB Total SNPs: 257

Non-coding: 250 | Synonymous: 5 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 307 | Molecular Weight (kDa): 36.541

UniProt ID(s): A0A144A3H3

PDB ID(s): None

Isoelectric Point: 7.45

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104