PF3D7_1425500

Genome location: Pf3D7_14_v3:993,652..994,661(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.00	1.00
Trophozoite	not expressed	0.01	0.99
Schizont	not expressed	0.02	0.98
Gametocyte	expressed	0.74	0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1425500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.301 | #Insertions: 5

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1019000)

Relative Growth Rate: 1.07 ± 0.18
Confidence: 4.86

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1019000)

Modification: Disrupted | RMgm-2810

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILK8

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_106500

Most Similar Human Ortholog: A6NNX1

TM-align score: 0.49 | RMSD: 2.99

Seq Identity: 0.23 | Length: 60 / 175

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000178796	regulatory subunit of type II PKA R-subunit domain containing 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	9	2	10
disruptive	4	10	11	30
missense	4	10	10	26

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	19	5	9
disruptive	7	30	19	40
missense	6	23	16	28

PlasmoDB Total SNPs: 66

Non-coding: 61 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 175 | Molecular Weight (kDa): 21.337

UniProt ID(s): Q8ILK8

PDB ID(s): None

Isoelectric Point: 6.88

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF47391	N/A