PF3D7_1425600

Genome location: Pf3D7_14_v3:994,688..1,001,019(-)

Genome classification: Core

Function and Localization

Product Description: zinc finger protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.03	0.99
Trophozoite	possibly expressed	0.08	0.96
Schizont	not expressed	0.05	0.97
Gametocyte	possibly expressed	0.84	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1425600

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.462 | #Insertions: 2

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1134900)

Relative Growth Rate: 0.03 ± 0.17
Confidence: 4.93

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILK7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_101179

Most Similar Human Ortholog: G3V2P5

TM-align score: 0.27 | RMSD: 4.71

Seq Identity: 0.21 | Length: 80 / 1781

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000185650	ZFP36 ring finger protein like 1

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	17	51	46	87
disruptive	80	238	138	346
missense	39	169	113	305

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	138	57	119
disruptive	157	506	247	535
missense	68	388	208	385

PlasmoDB Total SNPs: 291

Non-coding: 82 | Synonymous: 122 | Nonsynonymous: 86 | Stop Codon: 1

Protein Information

Protein Length: 1781 | Molecular Weight (kDa): 211.75

UniProt ID(s): Q8ILK7

PDB ID(s): None

Isoelectric Point: 6

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000571	Zinc finger, CCCH-type
InterPro	IPR036855	Zinc finger, CCCH-type superfamily
PFam	N/A	N/A
Superfamily	SSF90229	Zinc finger, CCCH-type superfamily