PF3D7_1425700

Genome location: Pf3D7_14_v3:1,005,996..1,008,490(+)

Genome classification: Core

Function and Localization

Product Description: vacuolar ER assembly factor VMA12, putative

SignalP Peptide: N/A

# Transmembrane Domains: 2

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0012505	endomembrane system

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	0.23	0.89
Trophozoite	possibly expressed	0.49	0.71
Schizont	possibly expressed	0.24	0.84
Gametocyte	not expressed	0.46	0.73

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1425700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.149 | MFS: -2.69 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILK6

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533072

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	4	5	5	17
disruptive	5	30	17	47
missense	5	28	16	42

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	27	8	27
disruptive	16	84	41	94
missense	10	63	33	71

PlasmoDB Total SNPs: 141

Non-coding: 129 | Synonymous: 6 | Nonsynonymous: 6 | Stop Codon: 0

Protein Information

Protein Length: 359 | Molecular Weight (kDa): 42.824

UniProt ID(s): Q8ILK6

PDB ID(s): None

Isoelectric Point: 8.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR021013	ATPase, vacuolar ER assembly factor, Vma12
PFam	N/A	N/A
Superfamily	N/A	N/A