PF3D7_1425800

Genome location: Pf3D7_14_v3:1,008,510..1,012,651(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.10	0.95
Trophozoite	possibly expressed	0.47	0.73
Schizont	not expressed	0.59	0.68
Gametocyte	not expressed	0.72	0.61

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1425800

Resistome Missense Mutations: Q62K, D792E

Resistome Compounds with Missense Mutations: KAI407, MMV1490405

Resistome # Samples with Disruptive Mutations: 3 (3 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.181 | MFS: -2.928 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILK5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532429

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	11	31	19	53
disruptive	61	181	95	187
missense	28	116	56	129

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	16	66	28	52
disruptive	140	326	133	253
missense	59	212	85	146

PlasmoDB Total SNPs: 250

Non-coding: 98 | Synonymous: 94 | Nonsynonymous: 58 | Stop Codon: 0

Protein Information

Protein Length: 966 | Molecular Weight (kDa): 115.156

UniProt ID(s): Q8ILK5

PDB ID(s): None

Isoelectric Point: 4.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A