Product Description: protein HGH1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.52 | 0.75 |
| Trophozoite | expressed | 0.31 | 0.83 |
| Schizont | not expressed | 0.06 | 0.96 |
| Gametocyte | not expressed | 0.31 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1425900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.913 | MFS: -2.92 | #Insertions: 1
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILK4
"Best" AlphaFill ligand hit: ATP (adenosine-5'-triphosphate, Local RMSD=7.14) with 6JWQ (Global RMSD=17.91)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_103137
Most Similar Human Ortholog: Q9BTY7
TM-align score: 0.71 | RMSD: 3.74
Seq Identity: 0.15 | Length: 316 / 368
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000235173 | HGH1 homolog |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 1 | 16 | 13 | 19 |
| disruptive | 1 | 10 | 13 | 36 |
| missense | 1 | 10 | 12 | 32 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 39 | 15 | 26 |
| disruptive | 7 | 48 | 30 | 79 |
| missense | 1 | 37 | 23 | 52 |
PlasmoDB Total SNPs: 100
Non-coding: 87 | Synonymous: 12 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 368 | Molecular Weight (kDa): 43.161
UniProt ID(s): Q8ILK4
PDB ID(s): None
Isoelectric Point: 4.81
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR007205 | Protein HGH1 N-terminal |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR039717 | Protein Hgh1 |
| PFam | PF04063 | Protein HGH1 N-terminal |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |