Genome location: Pf3D7_14_v3:1,018,646..1,020,564(-)
Genome classification: Core
Product Description: transcription factor BTF3, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005829 | cytosol |
| Component | GO:0005854 | nascent polypeptide-associated complex |
| Component | GO:0005634 | nucleus |
| Component | GO:0042788 | polysomal ribosome |
| Component | GO:0005667 | transcription regulator complex |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.99 | 0.57 |
| Trophozoite | expressed | 1.38 | 0.42 |
| Schizont | expressed | 0.13 | 0.93 |
| Gametocyte | possibly expressed | 0.47 | 0.74 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1426100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.204 | MFS: -2.717 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1018500)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILK2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101091
Most Similar Human Ortholog: A0A7I2YQL2
TM-align score: 0.52 | RMSD: 3.49
Seq Identity: 0.21 | Length: 87 / 171
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000134717 | basic transcription factor 3 like 4 |
| ENSG00000145741 | basic transcription factor 3 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 0 | 1 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 0 | 1 | 0 |
| disruptive | 0 | 0 | 0 | 0 |
| missense | 0 | 0 | 0 | 0 |
PlasmoDB Total SNPs: 58
Non-coding: 55 | Synonymous: 3 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 171 | Molecular Weight (kDa): 19.393
UniProt ID(s): Q8ILK2
PDB ID(s): None
Isoelectric Point: 9.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002715 | Nascent polypeptide-associated complex NAC domain |
| InterPro | IPR039370 | Transcription factor BTF3 |
| PFam | PF01849 | Nascent polypeptide-associated complex NAC domain |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |
| 34844560 | Construction of yeast one-hybrid library and screening of transcription factorsregulating LhMYBSPLATTER expression in Asiatic hybrid lilies (Lilium spp.) | Cao Y, Bi M, ..., Ming J | 10.1186/s12870-021-03347-1 |