PF3D7_1426300

Genome location: Pf3D7_14_v3:1,023,202..1,025,765(-)

Genome classification: Core

Function and Localization

Product Description: dynein intermediate chain, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0005856	cytoskeleton
Component	GO:0036157	outer dynein arm
Function	GO:0045504	dynein heavy chain binding
Function	GO:0045503	dynein light chain binding
Function	GO:0003777	microtubule motor activity
Process	GO:0003341	cilium movement
Process	GO:0007018	microtubule-based movement
Process	GO:0036158	outer dynein arm assembly

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	0.99
Trophozoite	not expressed	0.07	0.96
Schizont	not expressed	0.12	0.91
Gametocyte	expressed	0.52	0.74

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1426300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 0.886 | MFS: -2.624 | #Insertions: 1

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1018300)

Relative Growth Rate: 0.96 ± 0.12
Confidence: 5.68

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1018300)

Modification: Disrupted | RMgm-2807

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3I1

"Best" AlphaFill ligand hit: ALQ (2-methyl-propionic acid, Local RMSD=0.46) with 4GM8 (Global RMSD=14.81)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_104087

Most Similar Human Ortholog: J3QRG2

TM-align score: 0.66 | RMSD: 3.75

Seq Identity: 0.29 | Length: 457 / 605

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000171595	dynein axonemal intermediate chain 2

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	26	12	40
disruptive	6	29	16	52
missense	2	28	15	47

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	4	58	17	40
disruptive	13	71	32	100
missense	6	56	27	71

PlasmoDB Total SNPs: 54

Non-coding: 26 | Synonymous: 16 | Nonsynonymous: 12 | Stop Codon: 0

Protein Information

Protein Length: 605 | Molecular Weight (kDa): 71.314

UniProt ID(s): C6S3I1

PDB ID(s): None

Isoelectric Point: 7.98

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001680	WD40 repeat
InterPro	IPR019775	WD40 repeat, conserved site
InterPro	IPR036322	WD40-repeat-containing domain superfamily
PFam	N/A	N/A
Superfamily	SSF50978	WD40-repeat-containing domain superfamily