PF3D7_1426400

Genome location: Pf3D7_14_v3:1,026,262..1,027,215(-)

Genome classification: Core

Function and Localization

Product Description: MORN repeat protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.01	1.00
Trophozoite	not expressed	0.04	0.97
Schizont	not expressed	0.08	0.94
Gametocyte	expressed	0.44	0.76

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1426400

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS *tentative

MIS: 0.119 | MFS: -3.043 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1018200)

Modification: Disrupted | RMgm-262

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: C6S3I2

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_105927

Most Similar Human Ortholog: A0A0A0MTF6

TM-align score: 0.59 | RMSD: 2.11

Seq Identity: 0.36 | Length: 67 / 148

All Human Orthologs (OrthoMCL):

Gene ID	Description
ENSG00000185681	MORN repeat containing 5

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	1	7	5	12
disruptive	3	18	7	12
missense	3	18	7	10

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	2	16	7	5
disruptive	6	27	8	18
missense	4	25	7	15

PlasmoDB Total SNPs: 42

Non-coding: 37 | Synonymous: 3 | Nonsynonymous: 2 | Stop Codon: 0

Protein Information

Protein Length: 148 | Molecular Weight (kDa): 17.939

UniProt ID(s): C6S3I2

PDB ID(s): None

Isoelectric Point: 5.38

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR003409	MORN motif
InterPro	IPR042814	MORN repeat-containing protein 5
PFam	PF02493	MORN motif
Superfamily	SSF82185	N/A