Genome location: Pf3D7_14_v3:1,027,682..1,030,025(-)
Genome classification: Core
Product Description: ABC transporter G family member 2
SignalP Peptide: N/A
# Transmembrane Domains: 6
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0045177 | apical part of cell |
| Component | GO:0005886 | plasma membrane |
| Function | GO:0042626 | ATPase-coupled transmembrane transporter activity |
| Function | GO:0005319 | lipid transporter activity |
| Process | GO:0006869 | lipid transport |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.02 | 0.99 |
| Trophozoite | possibly expressed | 0.03 | 0.98 |
| Schizont | possibly expressed | 0.05 | 0.96 |
| Gametocyte | expressed | 1.29 | 0.58 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1426500
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -1.22 | #Insertions: 3
PlasmoGEM Phenotype: Slow (Pb ortholog: PBANKA_1018100)
RMgmDB ABS Phenotype: Not different from wild type (Pb ortholog: PBANKA_1018100)
Modification: Mutated | RMgm-4836
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILJ9
"Best" AlphaFill ligand hit: UMQ (undecyl-maltoside, Local RMSD=0.05) with 4KI0 (Global RMSD=3.08)
No associated EC numbersOrthology to BindingDB Entries:
| UniProt | Protein Name | Species | Homology Source | BindingDB Ligands |
|---|---|---|---|---|
| Q9UNQ0 | Broad substrate specificity ATP-binding cassette transporter ABCG2 | Homo sapiens | HOGENOM, OMA | Botryllamide G, 7Fumitremorgin Ccid_223753NSC19139... |
Ortholog Group (OrthoMCL): OG6_100076
Most Similar Human Ortholog: Q9H221
TM-align score: 0.81 | RMSD: 2.74
Seq Identity: 0.23 | Length: 571 / 660
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000118777 | ATP binding cassette subfamily G member 2 (Junior blood group) |
| ENSG00000143921 | ATP binding cassette subfamily G member 8 |
| ENSG00000160179 | ATP binding cassette subfamily G member 1 |
| ENSG00000172350 | ATP binding cassette subfamily G member 4 |
Protein Length: 660 | Molecular Weight (kDa): 75.478
UniProt ID(s): Q8ILJ9
PDB ID(s): None
Isoelectric Point: 9.27
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003439 | ABC transporter-like |
| InterPro | IPR003593 | AAA+ ATPase domain |
| InterPro | IPR013525 | ABC-2 type transporter |
| InterPro | IPR017871 | ABC transporter, conserved site |
| InterPro | IPR027417 | P-loop containing nucleoside triphosphate hydrolase |
| PFam | PF00005 | ABC transporter-like |
| PFam | PF01061 | ABC-2 type transporter |
| Superfamily | SSF52540 | P-loop containing nucleoside triphosphate hydrolase |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 25 | 15 | 41 |
| disruptive | 2 | 6 | 4 | 26 |
| missense | 2 | 6 | 4 | 25 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 55 | 26 | 39 |
| disruptive | 3 | 25 | 33 | 59 |
| missense | 2 | 16 | 28 | 47 |
PlasmoDB Total SNPs: 74
Non-coding: 53 | Synonymous: 19 | Nonsynonymous: 2 | Stop Codon: 0
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 25198203 | A female gametocyte-specific ABC transporter plays a role in lipid metabolism inthe malaria parasite. | Tran PN, Brown SH, ..., Maier AG | 10.1038/ncomms5773 |
| 26239803 | Characterization of native PfABCG protein in Plasmodium falciparum. | Edaye S, Georges E | 10.1016/j.bcp.2015.06.035 |