PF3D7_1426800

Genome location: Pf3D7_14_v3:1,042,553..1,049,929(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	1.50	0.40
Trophozoite	expressed	0.93	0.52
Schizont	expressed	0.33	0.81
Gametocyte	not expressed	0.89	0.56

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1426800

Resistome Missense Mutations: Q699H

Resistome Compounds with Missense Mutations: MMV982556

Resistome # Samples with Disruptive Mutations: 2 (2 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.13 | MFS: -2.881 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILJ6

"Best" AlphaFill ligand hit: U5P (uridine-5'-monophosphate, Local RMSD=0.07) with 6DSR (Global RMSD=24.18)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533262

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	27	82	40	95
disruptive	90	255	152	340
missense	51	151	92	233

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	50	156	75	128
disruptive	199	640	296	693
missense	90	371	204	355

PlasmoDB Total SNPs: 404

Non-coding: 112 | Synonymous: 166 | Nonsynonymous: 126 | Stop Codon: 0

Protein Information

Protein Length: 2082 | Molecular Weight (kDa): 248.503

UniProt ID(s): Q8ILJ6

PDB ID(s): None

Isoelectric Point: 9.23

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A