Genome location: Pf3D7_14_v3:1,049,648..1,050,707(-)
Genome classification: Core
Product Description: cytochrome b-c1 complex subunit 6, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 1.10.2.2 (Transferred entry: 7.1.1.8)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005750 | mitochondrial respiratory chain complex III |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0008121 | ubiquinol-cytochrome-c reductase activity |
| Process | GO:0009060 | aerobic respiration |
| Process | GO:0006122 | mitochondrial electron transport, ubiquinol to cytochrome c |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.14 | 0.93 |
| Trophozoite | expressed | 0.84 | 0.55 |
| Schizont | expressed | 1.00 | 0.48 |
| Gametocyte | expressed | 0.89 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1426900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 0.23 | MFS: -2.492 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1017700)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILJ5
"Best" AlphaFill ligand hit: No AlphaFill hits
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 1.10.2.2 | quinol-cytochrome-c reductase | No BRENDA inhibitors |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102683
Most Similar Human Ortholog: A0A096LP55
TM-align score: 0.71 | RMSD: 1.82
Seq Identity: 0.27 | Length: 71 / 88
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000233954 | ubiquinol-cytochrome c reductase hinge protein like |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
No passing variants found
PlasmoDB Total SNPs: 34
Non-coding: 32 | Synonymous: 2 | Nonsynonymous: 0 | Stop Codon: 0
Protein Length: 88 | Molecular Weight (kDa): 10.587
UniProt ID(s): Q8ILJ5
PDB ID(s): None
Isoelectric Point: 7.92
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR003422 | Cytochrome b-c1 complex, subunit 6 |
| InterPro | IPR023184 | Ubiquinol-cytochrome C reductase hinge domain |
| InterPro | IPR036811 | Ubiquinol-cytochrome C reductase hinge domain superfamily |
| PFam | PF02320 | Ubiquinol-cytochrome C reductase hinge domain |
| Superfamily | SSF81531 | Ubiquinol-cytochrome C reductase hinge domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |
| 8138552 | Acidic regions of cytochrome c1 are essential for ubiquinol-cytochrome creductase activity in yeast cells lacking the acidic QCR6 protein | Nakai M, Endo T, ..., Matsubara H | 10.1093/oxfordjournals.jbchem.a124277 |
| 8175712 | Isolation and characterization of QCR10, the nuclear gene encoding the 8.5-kDasubunit 10 of the Saccharomyces cerevisiae cytochrome bc1 complex | Brandt U, Uribe S, Schagger H, Trumpower BL | https://pubmed.ncbi.nlm.nih.gov/8175712/ |
| 10873857 | Structure at 2.3 A resolution of the cytochrome bc(1) complex from the yeastSaccharomyces cerevisiae co-crystallized with an antibody Fv fragment | Hunte C, Koepke J, ..., Michel H | 10.1016/s0969-2126(00)00152-0 |
| 7730379 | QSR1, an essential yeast gene with a genetic relationship to a subunit of themitochondrial cytochrome bc1 complex, is homologous to a gene implicated ineukaryotic cell differentiation | Tron T, Yang M, ..., Trumpower BL | 10.1074/jbc.270.17.9961 |
| 10338132 | The cleaved presequence is not required for import of subunit 6 of the cytochromebc1 complex into yeast mitochondria or assembly into the complex | DeLabre ML, Nett JH, Trumpower BL | 10.1016/s0014-5793(99)00415-9 |
| 8288589 | Deletion of QCR6, the gene encoding subunit six of the mitochondrial cytochromebc1 complex, blocks maturation of cytochrome c1, and causes temperature-sensitivepetite growth in Saccharomyces cerevisiae | Yang M, Trumpower BL | https://pubmed.ncbi.nlm.nih.gov/8288589/ |
| 19236481 | Evidence that the assembly of the yeast cytochrome bc1 complex involves theformation of a large core structure in the inner mitochondrial membrane | Zara V, Conte L, Trumpower BL | 10.1111/j.1742-4658.2009.06916.x |
| 34335494 | Genome-Scale Screening and Combinatorial Optimization of Gene OverexpressionTargets to Improve Cadmium Tolerance in Saccharomyces cerevisiae | Chen Y, Liang J, ..., Si T | 10.3389/fmicb.2021.662512 |
| 9148960 | QSR1, an essential yeast gene with a genetic relationship to a subunit of themitochondrial cytochrome bc1 complex, codes for a 60 S ribosomal subunit protein | Dick FA, Karamanou S, Trumpower BL | 10.1074/jbc.272.20.13372 |
| 25435378 | Enhanced hexose fermentation by Saccharomyces cerevisiae through integration ofstoichiometric modeling and genetic screening | Quarterman J, Kim SR, Kim PJ, Jin YS | 10.1016/j.jbiotec.2014.11.017 |
| 2170363 | Subunit 6 regulates half-of-the-sites reactivity of the dimeric cytochrome bc1complex in Saccharomyces cerevisiae | Schmitt ME, Trumpower BL | https://pubmed.ncbi.nlm.nih.gov/2170363/ |
| 8686381 | Fifteen open reading frames in a 30.8 kb region of the right arm of chromosome VIfrom Saccharomyces cerevisiae | Eki T, Naitou M, ..., et al. | 10.1002/(SICI)1097-0061(199602)12:2<177::AID-YEA896>3.0.CO;2-A |