PF3D7_1427000

Genome location: Pf3D7_14_v3:1,050,744..1,055,499(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0020011	apicoplast
Function	GO:0003755	peptidyl-prolyl cis-trans isomerase activity
Function	GO:0044183	protein folding chaperone
Function	GO:0043022	ribosome binding
Process	GO:0051083	'de novo' cotranslational protein folding
Process	GO:0061077	chaperone-mediated protein folding
Process	GO:0043335	protein unfolding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.28	0.87
Trophozoite	possibly expressed	0.97	0.51
Schizont	possibly expressed	0.91	0.54
Gametocyte	not expressed	0.87	0.55

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1427000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.122 | MFS: -3.13 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILJ4

"Best" AlphaFill ligand hit: NAI (nadh, Local RMSD=3.69) with 3WGH (Global RMSD=25.60)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532930

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	7	31	26	50
disruptive	29	96	59	164
missense	25	91	52	143

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	13	72	41	67
disruptive	65	245	124	317
missense	43	201	100	173

PlasmoDB Total SNPs: 133

Non-coding: 64 | Synonymous: 39 | Nonsynonymous: 30 | Stop Codon: 0

Protein Information

Protein Length: 1169 | Molecular Weight (kDa): 140.47

UniProt ID(s): Q8ILJ4

PDB ID(s): None

Isoelectric Point: 6.82

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR005215	Trigger factor
InterPro	IPR027304	Trigger factor/SurA domain superfamily
PFam	N/A	N/A
Superfamily	SSF109998	Trigger factor/SurA domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
30212465	Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites.	Boucher MJ, Ghosh S, ..., Yeh E	10.1371/journal.pbio.2005895