About Gene List

PF3D7_1427300

Genome location: Pf3D7_14_v3:1,064,142..1,069,386(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0005634 nucleus

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.10 0.95
Trophozoite not expressed 0.56 0.68
Schizont not expressed 0.33 0.80
Gametocyte expressed 0.69 0.62

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1427300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.126 | MFS: -3.157 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILJ1

"Best" AlphaFill ligand hit: PTY (phosphatidylethanolamine, Local RMSD=0.25) with 2VWA (Global RMSD=37.23)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_167120

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 16 83 36 68
disruptive 9 49 41 107
missense 3 44 39 85

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 32 150 45 49
disruptive 18 140 87 186
missense 7 118 61 120

PlasmoDB Total SNPs: 103

Non-coding: 30 | Synonymous: 60 | Nonsynonymous: 13 | Stop Codon: 0

Protein Information

Protein Length: 1477 | Molecular Weight (kDa): 175.761

UniProt ID(s): Q8ILJ1

PDB ID(s): None

Isoelectric Point: 7.29

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
16267556 A protein interaction network of the malaria parasite Plasmodium falciparum. LaCount DJ, Vignali M, ..., Hughes RE 10.1038/nature04104
23181666 Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. Oehring SC, Woodcroft BJ, ..., Voss TS 10.1186/gb-2012-13-11-r108