Product Description: leucine-rich repeat protein
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0042393 | histone binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | possibly expressed | 0.28 | 0.87 |
| Trophozoite | expressed | 1.61 | 0.31 |
| Schizont | expressed | 0.53 | 0.69 |
| Gametocyte | possibly expressed | 0.76 | 0.60 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1427900
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.132 | MFS: -3.026 | #Insertions: 0
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILI6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_102163
Most Similar Human Ortholog: H0YN26
TM-align score: 0.82 | RMSD: 1.85
Seq Identity: 0.28 | Length: 158 / 281
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000136938 | acidic nuclear phosphoprotein 32 family member B |
| ENSG00000140350 | acidic nuclear phosphoprotein 32 family member A |
| ENSG00000143401 | acidic nuclear phosphoprotein 32 family member E |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 7 | 1 | 19 |
| disruptive | 2 | 10 | 3 | 17 |
| missense | 1 | 8 | 2 | 13 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 5 | 13 | 10 | 22 |
| disruptive | 4 | 26 | 9 | 42 |
| missense | 1 | 14 | 8 | 26 |
PlasmoDB Total SNPs: 139
Non-coding: 126 | Synonymous: 10 | Nonsynonymous: 2 | Stop Codon: 1
Protein Length: 281 | Molecular Weight (kDa): 33.006
UniProt ID(s): A0A144A431, Q8ILI6
PDB ID(s): None
Isoelectric Point: 4
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | PF14580 | N/A |
| Superfamily | SSF52058 | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 15895553 | The Anp32 family of proteins containing leucine-rich repeats. | Matilla A, Radrizzani M | 10.1080/14734220410019020 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |