About Gene List

PF3D7_1428000

Genome location: Pf3D7_14_v3:1,094,297..1,097,880(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium membrane protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 10

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0016020 membrane

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring possibly expressed 0.01 1.00
Trophozoite expressed 0.05 0.97
Schizont expressed 0.07 0.94
Gametocyte expressed 0.10 0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1428000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.051 | #Insertions: 4

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILI5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_533708

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 4 11 9 19
disruptive 3 17 9 36
missense 3 16 9 33

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 5 26 13 23
disruptive 10 37 22 71
missense 5 30 19 53

PlasmoDB Total SNPs: 215

Non-coding: 201 | Synonymous: 13 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 414 | Molecular Weight (kDa): 49.81

UniProt ID(s): Q8ILI5

PDB ID(s): None

Isoelectric Point: 9.58

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
11152613 Predicting transmembrane protein topology with a hidden Markov model: applicationto complete genomes. Krogh A, Larsson B, von Heijne G, Sonnhammer EL 10.1006/jmbi.2000.4315
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097