Genome location: Pf3D7_14_v3:1,097,756..1,100,391(-)
Genome classification: Core
Product Description: WW domain-binding protein 11, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005681 | spliceosomal complex |
| Process | GO:0045292 | mRNA cis splicing, via spliceosome |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.29 | 0.86 |
| Trophozoite | expressed | 0.28 | 0.82 |
| Schizont | expressed | 0.55 | 0.68 |
| Gametocyte | expressed | 0.43 | 0.75 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1428100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: -2.311 | #Insertions: 4
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1016500)
Modification: Disrupted | RMgm-2798
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILI4
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 31 | 14 | 35 |
| disruptive | 25 | 112 | 57 | 142 |
| missense | 17 | 89 | 49 | 120 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 12 | 46 | 27 | 44 |
| disruptive | 56 | 226 | 94 | 183 |
| missense | 31 | 176 | 74 | 134 |
PlasmoDB Total SNPs: 154
Non-coding: 85 | Synonymous: 37 | Nonsynonymous: 32 | Stop Codon: 0
Protein Length: 637 | Molecular Weight (kDa): 75.076
UniProt ID(s): Q8ILI4
PDB ID(s): None
Isoelectric Point: 8
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR019007 | WW domain binding protein 11 |
| PFam | PF09429 | WW domain binding protein 11 |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 18474590 | Kex1 protease is involved in yeast cell death induced by defectiveN-glycosylation, acetic acid, and chronological aging | Hauptmann P, Lehle L | 10.1074/jbc.M801303200 |
| 16420350 | Defects in N-glycosylation induce apoptosis in yeast | Hauptmann P, Riel C, ..., Lehle L | 10.1111/j.1365-2958.2005.04981.x |
| 17827536 | Construction of two recombination yeast two-hybrid vectors by in vitrorecombination | Guo F, Wang Y, Zhang YZ | 10.1007/s12033-007-0018-0 |