Product Description: proliferation-associated protein 2g4, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005634 | nucleus |
| Function | GO:0008235 | metalloexopeptidase activity |
| Process | GO:0007050 | cell cycle arrest |
| Process | GO:0008283 | cell population proliferation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.85 | 0.62 |
| Trophozoite | expressed | 1.00 | 0.48 |
| Schizont | expressed | 0.21 | 0.86 |
| Gametocyte | expressed | 0.44 | 0.76 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1428300
Resistome Missense Mutations: H274Y
Resistome Compounds with Missense Mutations: GNF-Pf-5611
Resistome # Samples with Disruptive Mutations: 3 (3 missense, 3 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.023 | #Insertions: 5
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILI2
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101895
Most Similar Human Ortholog: F8VR77
TM-align score: 0.92 | RMSD: 1.78
Seq Identity: 0.31 | Length: 275 / 377
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000170515 | proliferation-associated 2G4 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 19 | 5 | 18 |
| disruptive | 1 | 14 | 9 | 33 |
| missense | 1 | 13 | 9 | 28 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 8 | 36 | 13 | 23 |
| disruptive | 7 | 46 | 28 | 92 |
| missense | 3 | 37 | 21 | 72 |
PlasmoDB Total SNPs: 131
Non-coding: 114 | Synonymous: 11 | Nonsynonymous: 6 | Stop Codon: 0
Protein Length: 377 | Molecular Weight (kDa): 42.641
UniProt ID(s): Q8ILI2
PDB ID(s): None
Isoelectric Point: 7.84
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000994 | Peptidase M24 |
| InterPro | IPR036005 | Creatinase/aminopeptidase-like |
| InterPro | IPR036390 | Winged helix DNA-binding domain superfamily |
| PFam | PF00557 | Peptidase M24 |
| Superfamily | SSF46785 | Winged helix DNA-binding domain superfamily |
| Superfamily | SSF55920 | Creatinase/aminopeptidase-like |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 23181666 | Organellar proteomics reveals hundreds of novel nuclear proteins in the malariaparasite Plasmodium falciparum. | Oehring SC, Woodcroft BJ, ..., Voss TS | 10.1186/gb-2012-13-11-r108 |
| 30379851 | Identification of Plasmodium falciparum nuclear proteins by mass spectrometry andproposed protein annotation. | Briquet S, Ourimi A, ..., Vaquero C | 10.1371/journal.pone.0205596 |