Genome location: Pf3D7_14_v3:1,108,066..1,116,168(-)
Genome classification: Core
Product Description: WD and tetratricopeptide repeats protein 1, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB): None
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.05 | 0.98 |
| Trophozoite | not expressed | 0.15 | 0.92 |
| Schizont | not expressed | 0.05 | 0.97 |
| Gametocyte | possibly expressed | 1.16 | 0.45 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1428400
Resistome Missense Mutations: D476Y
Resistome Compounds with Missense Mutations: Cipargamin/KAE609/NITD609
Resistome # Samples with Disruptive Mutations: 2 (2 missense, 2 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 1 | MFS: 0.461 | #Insertions: 2
PlasmoGEM Phenotype: N/A
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: A0A5K1K965
"Best" AlphaFill ligand hit: SIW (keggin (sta), Local RMSD=0.03) with 6Y7O (Global RMSD=2.33)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_104422
Most Similar Human Ortholog: Q8N5D0
TM-align score: 0.60 | RMSD: 4.02
Seq Identity: 0.26 | Length: 452 / 2020
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000142784 | WD and tetratricopeptide repeats 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 20 | 70 | 44 | 105 |
| disruptive | 79 | 186 | 109 | 247 |
| missense | 46 | 139 | 87 | 197 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 35 | 143 | 62 | 139 |
| disruptive | 153 | 445 | 190 | 452 |
| missense | 79 | 323 | 151 | 312 |
PlasmoDB Total SNPs: 359
Non-coding: 151 | Synonymous: 95 | Nonsynonymous: 113 | Stop Codon: 0
Protein Length: 2020 | Molecular Weight (kDa): 240.218
UniProt ID(s): A0A5K1K965
PDB ID(s): None
Isoelectric Point: 8.43
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR001680 | WD40 repeat |
| InterPro | IPR011990 | Tetratricopeptide-like helical domain superfamily |
| InterPro | IPR019775 | WD40 repeat, conserved site |
| InterPro | IPR036322 | WD40-repeat-containing domain superfamily |
| PFam | PF00400 | WD40 repeat |
| Superfamily | SSF48452 | Tetratricopeptide-like helical domain superfamily |
| Superfamily | SSF50978 | WD40-repeat-containing domain superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 12368868 | Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14. | Gardner MJ, Shallom SJ, ..., Fraser CM | 10.1038/nature01094 |