PF3D7_1428700

Genome location: Pf3D7_14_v3:1,129,223..1,132,227(-)

Genome classification: Core

Function and Localization

Product Description: heme/steroid binding domain containing protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0043231	intracellular membrane-bounded organelle
Component	GO:0016020	membrane
Function	GO:0009055	electron transfer activity
Function	GO:0020037	heme binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	expressed	0.05	0.97
Trophozoite	expressed	0.16	0.89
Schizont	expressed	0.10	0.92
Gametocyte	expressed	0.11	0.93

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1428700

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.758 | #Insertions: 2

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILH7

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_115676

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	1
disruptive	0	0	0	0
missense	0	0	0	0

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	0	0	0	1
disruptive	0	0	0	0
missense	0	0	0	0

PlasmoDB Total SNPs: 175

Non-coding: 127 | Synonymous: 23 | Nonsynonymous: 25 | Stop Codon: 0

Protein Information

Protein Length: 433 | Molecular Weight (kDa): 51.444

UniProt ID(s): Q8ILH7

PDB ID(s): None

Isoelectric Point: 8.28

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR001199	Cytochrome b5-like heme/steroid binding domain
InterPro	IPR018506	Cytochrome b5, heme-binding site
InterPro	IPR036400	Cytochrome b5-like heme/steroid binding domain superfamily
PFam	PF00173	Cytochrome b5-like heme/steroid binding domain
Superfamily	SSF55856	Cytochrome b5-like heme/steroid binding domain superfamily

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094