PF3D7_1428800

Genome location: Pf3D7_14_v3:1,132,046..1,134,562(+)

Genome classification: Core

Function and Localization

Product Description: transcription initiation TFIID-like, putative

SignalP Peptide: N/A

# Transmembrane Domains: 1

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Function	GO:0016251	RNA polymerase II general transcription initiation factor activity
Process	GO:0006352	DNA-templated transcription, initiation

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	nd	nd
Trophozoite	expressed	nd	nd
Schizont	expressed	nd	nd
Gametocyte	expressed	nd	nd

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1428800.2

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.152 | MFS: -3.282 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1015900)

Relative Growth Rate: 0.09 ± 0.13
Confidence: 5.41

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: A0A144A3A5

"Best" AlphaFill ligand hit: LFA (lipid fragment, Local RMSD=0.66) with 5W17 (Global RMSD=20.76)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_133547

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	10	14	21
disruptive	2	27	14	41
missense	2	26	12	33

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	5	31	20	21
disruptive	8	85	37	104
missense	7	63	31	58

PlasmoDB Total SNPs: 31

Non-coding: 16 | Synonymous: 7 | Nonsynonymous: 8 | Stop Codon: 0

Protein Information

Protein Length: 367 | Molecular Weight (kDa): 41.978

UniProt ID(s): Q8ILH6

PDB ID(s): None

Isoelectric Point: 9.7

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR000814	TATA-box binding protein
PFam	PF00352	TATA-box binding protein
Superfamily	SSF55945	N/A