PF3D7_1428900

Genome location: Pf3D7_14_v3:1,134,187..1,139,679(-)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.11	0.95
Trophozoite	expressed	0.86	0.55
Schizont	expressed	0.39	0.78
Gametocyte	expressed	0.54	0.70

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1428900

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.128 | MFS: -2.844 | #Insertions: 0

PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1015800)

Relative Growth Rate: 0.07 ± 0.12
Confidence: 5.61

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILH5

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532697

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	15	51	27	73
disruptive	43	155	71	152
missense	16	112	60	113

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	26	109	54	74
disruptive	84	301	145	343
missense	36	209	102	220

PlasmoDB Total SNPs: 241

Non-coding: 50 | Synonymous: 112 | Nonsynonymous: 78 | Stop Codon: 1

Protein Information

Protein Length: 1445 | Molecular Weight (kDa): 172.15

UniProt ID(s): Q8ILH5

PDB ID(s): None

Isoelectric Point: 6.08

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	N/A	N/A