Product Description: ribosomal protein L15, apicoplast, putative
SignalP Peptide: MNYFLFFLFCSWILIKG
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0020011 | apicoplast |
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0000315 | organellar large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | possibly expressed | N/A | N/A |
| Ring | expressed | 0.12 | 0.94 |
| Trophozoite | expressed | 0.89 | 0.54 |
| Schizont | expressed | 0.32 | 0.82 |
| Gametocyte | expressed | 0.66 | 0.64 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1429100
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.126 | MFS: -3.091 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1015600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILH3
"Best" AlphaFill ligand hit: RB6 (bal 9141, bound form, Local RMSD=0.17) with 7RCY (Global RMSD=13.29)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100988
Most Similar Human Ortholog: E5RHF4
TM-align score: 0.59 | RMSD: 4.27
Seq Identity: 0.23 | Length: 165 / 545
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137547 | mitochondrial ribosomal protein L15 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 4 | 25 | 3 | 36 |
| disruptive | 4 | 20 | 15 | 40 |
| missense | 4 | 16 | 12 | 30 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 9 | 53 | 17 | 27 |
| disruptive | 20 | 62 | 37 | 116 |
| missense | 6 | 42 | 24 | 72 |
PlasmoDB Total SNPs: 76
Non-coding: 61 | Synonymous: 13 | Nonsynonymous: 2 | Stop Codon: 0
Protein Length: 545 | Molecular Weight (kDa): 64.759
UniProt ID(s): Q8ILH3
PDB ID(s): None
Isoelectric Point: 10.29
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005749 | Ribosomal protein L15, bacterial-type |
| InterPro | IPR021131 | Ribosomal protein L18e/L15P |
| InterPro | IPR030878 | Ribosomal protein L15 |
| InterPro | IPR036227 | Ribosomal L18e/L15P superfamily |
| PFam | PF00828 | Ribosomal protein L18e/L15P |
| Superfamily | SSF52080 | Ribosomal L18e/L15P superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 30212465 | Integrative proteomics and bioinformatic prediction enable a high-confidenceapicoplast proteome in malaria parasites. | Boucher MJ, Ghosh S, ..., Yeh E | 10.1371/journal.pbio.2005895 |