PF3D7_1429300

Genome location: Pf3D7_14_v3:1,150,188..1,153,847(-)

Genome classification: Core

Function and Localization

Product Description: CPW-WPC family protein

SignalP Peptide: MFSPNFFFFCFVFSQIKSVIS

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type	GO Term	Name
Component	GO:0044312	crystalloid

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	possibly expressed	N/A	N/A
Ring	expressed	0.02	0.99
Trophozoite	expressed	0.09	0.95
Schizont	expressed	0.04	0.98
Gametocyte	expressed	0.82	0.63

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1429300

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.794 | #Insertions: 3

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: Not tested (Pb ortholog: PBANKA_1015400)

Modification: Tagged | RMgm-4858

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILH1

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_176146

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	3	20	10	14
disruptive	6	19	12	36
missense	6	17	11	34

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	6	31	10	18
disruptive	14	43	31	86
missense	10	33	25	65

PlasmoDB Total SNPs: 237

Non-coding: 215 | Synonymous: 13 | Nonsynonymous: 9 | Stop Codon: 0

Protein Information

Protein Length: 371 | Molecular Weight (kDa): 43.241

UniProt ID(s): Q8ILH1

PDB ID(s): None

Isoelectric Point: 6.8

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR006387	CPW-WPC domain
PFam	PF09717	CPW-WPC domain
Superfamily	N/A	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
32736136	Plasmodium berghei LAPs form an extended protein complex that facilitatescrystalloid targeting and biogenesis.	Tremp AZ, Saeed S, ..., Dessens JT	10.1016/j.jprot.2020.103925