Product Description: ribosomal protein L15, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0005762 | mitochondrial large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.25 | 0.88 |
| Trophozoite | expressed | 0.64 | 0.64 |
| Schizont | expressed | 0.31 | 0.80 |
| Gametocyte | expressed | 0.95 | 0.52 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1429700
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.121 | MFS: -2.989 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1015600)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILG7
"Best" AlphaFill ligand hit: SPD (n-(2-amino-propyl)-1,4-diaminobutane, Local RMSD=0.80) with 4WFB (Global RMSD=13.46)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100988
Most Similar Human Ortholog: E5RHF4
TM-align score: 0.75 | RMSD: 2.88
Seq Identity: 0.23 | Length: 175 / 366
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000137547 | mitochondrial ribosomal protein L15 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 18 | 15 | 21 |
| disruptive | 4 | 17 | 14 | 31 |
| missense | 3 | 11 | 12 | 26 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 40 | 19 | 16 |
| disruptive | 17 | 51 | 31 | 68 |
| missense | 5 | 35 | 27 | 48 |
PlasmoDB Total SNPs: 96
Non-coding: 78 | Synonymous: 13 | Nonsynonymous: 5 | Stop Codon: 0
Protein Length: 366 | Molecular Weight (kDa): 43.634
UniProt ID(s): Q8ILG7
PDB ID(s): None
Isoelectric Point: 10.56
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR005749 | Ribosomal protein L15, bacterial-type |
| InterPro | IPR021131 | Ribosomal protein L18e/L15P |
| InterPro | IPR030878 | Ribosomal protein L15 |
| InterPro | IPR036227 | Ribosomal L18e/L15P superfamily |
| PFam | PF00828 | Ribosomal protein L18e/L15P |
| Superfamily | SSF52080 | Ribosomal L18e/L15P superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |