Product Description: coatomer subunit beta, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0030126 | COPI vesicle coat |
| Process | GO:0006888 | endoplasmic reticulum to Golgi vesicle-mediated transport |
| Process | GO:0006891 | intra-Golgi vesicle-mediated transport |
| Process | GO:0006890 | retrograde vesicle-mediated transport, Golgi to endoplasmic reticulum |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | expressed | 0.88 | 0.59 |
| Trophozoite | expressed | 0.95 | 0.51 |
| Schizont | expressed | 0.98 | 0.50 |
| Gametocyte | expressed | 0.70 | 0.62 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1429800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.12 | MFS: -3 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1014900)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILG6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100064
Most Similar Human Ortholog: E9PP63
TM-align score: 0.93 | RMSD: 1.36
Seq Identity: 0.40 | Length: 131 / 1370
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000129083 | COPI coat complex subunit beta 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 25 | 65 | 22 | 73 |
| disruptive | 30 | 99 | 53 | 140 |
| missense | 15 | 79 | 46 | 119 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 33 | 123 | 40 | 87 |
| disruptive | 53 | 211 | 98 | 243 |
| missense | 27 | 164 | 82 | 180 |
PlasmoDB Total SNPs: 340
Non-coding: 215 | Synonymous: 90 | Nonsynonymous: 35 | Stop Codon: 0
Protein Length: 1370 | Molecular Weight (kDa): 159.972
UniProt ID(s): Q8ILG6
PDB ID(s): None
Isoelectric Point: 6.15
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR002553 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| InterPro | IPR011710 | Coatomer beta subunit, C-terminal |
| InterPro | IPR016024 | Armadillo-type fold |
| InterPro | IPR016460 | Coatomer beta subunit (COPB1) |
| InterPro | IPR029446 | Coatomer beta subunit, appendage platform domain |
| PFam | PF01602 | Clathrin/coatomer adaptor, adaptin-like, N-terminal |
| PFam | PF07718 | Coatomer beta subunit, C-terminal |
| PFam | PF14806 | Coatomer beta subunit, appendage platform domain |
| Superfamily | SSF48371 | Armadillo-type fold |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |