PF3D7_1430000

Genome location: Pf3D7_14_v3:1,180,961..1,183,390(-)

Genome classification: Core

Function and Localization

Product Description: conserved protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 3

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	not expressed	0.23	0.88
Trophozoite	possibly expressed	0.59	0.66
Schizont	expressed	0.31	0.82
Gametocyte	expressed	0.61	0.66

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1430000

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: 0.352 | #Insertions: 11

PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1014700)

Relative Growth Rate: 0.99 ± 0.16
Confidence: 5.04

RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1014700)

Modification: Disrupted | RMgm-2785

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILG4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_109745

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	0	16	7	14
disruptive	4	22	26	47
missense	4	19	24	43

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	1	29	13	18
disruptive	10	75	35	94
missense	8	57	32	63

PlasmoDB Total SNPs: 106

Non-coding: 95 | Synonymous: 6 | Nonsynonymous: 5 | Stop Codon: 0

Protein Information

Protein Length: 329 | Molecular Weight (kDa): 39.396

UniProt ID(s): Q8ILG4

PDB ID(s): None

Isoelectric Point: 7.86

Protein Domain Annotations:

Source	Family ID	Description
InterPro	N/A	N/A
PFam	N/A	N/A
Superfamily	SSF81324	N/A

PMID	Title	Authors	DOI/Link
12368864	Genome sequence of the human malaria parasite Plasmodium falciparum.	Gardner MJ, Hall N, ..., Barrell B	10.1038/nature01097
12368868	Sequence of Plasmodium falciparum chromosomes 2, 10, 11 and 14.	Gardner MJ, Shallom SJ, ..., Fraser CM	10.1038/nature01094