Product Description: acid phosphatase, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: 2.7.4.21 (Inositol-hexakisphosphate kinase);2.7.4.24 (Diphosphoinositol-pentakisphosphate kinase);3.1.3.2 (Acid phosphatase)
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Function | GO:0033857 | diphosphoinositol-pentakisphosphate kinase activity |
| Function | GO:0000829 | inositol heptakisphosphate kinase activity |
| Function | GO:0000828 | inositol hexakisphosphate kinase activity |
| Process | GO:0006020 | inositol metabolic process |
| Process | GO:0032958 | inositol phosphate biosynthetic process |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | expressed | 0.69 | 0.70 |
| Trophozoite | expressed | 0.77 | 0.59 |
| Schizont | expressed | 0.19 | 0.89 |
| Gametocyte | expressed | 0.73 | 0.61 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1430300
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Mutable in CDS
MIS: 0.998 | MFS: -1.088 | #Insertions: 1
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1014400)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1014400)
Modification: Disrupted | RMgm-2783
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILG1
"Best" AlphaFill ligand hit: I7P ((1r,2r,3s,4s,5r,6s)-2,3,4,5,6-pentakis(phosphonooxy)cyclohexyl trihydrogen diphosphate, Local RMSD=0.41) with 3T9D (Global RMSD=3.33)
BRENDA EC Inhibitors:
| EC # | Name | EC Inhibitors |
|---|---|---|
| 2.7.4.21 | inositol-hexakisphosphate 5-kinase | BRENDA SOAP query unsuccessful |
| 2.7.4.24 | diphosphoinositol-pentakisphosphate 1-kinase | phosphategenisteinUNC10225498UNC10112646chlorpromazineC8-PtdIns(4,5)P2N-(6-Aminohexyl)-5-chloro-1-naphthalenesulfonamide2-O-benzyl-myo-inositol 1,2,3,4,6-pentakisphosphate2,5-O-benzyl-myo-inositol 1,3,4,6-tetrakisphosphate5-O-alpha-diphosphate-myo-inositol 1,3,4,6-tetrakisphosphate5-(phosphonoacetic acid ester)-1D-myo-inositol pentakisphosphate5-(phosphonoacetic acid ester)-1D-myo-inositol tetrakisphosphate... |
| 3.1.3.2 | acid phosphatase | ATPKClNEMSDSGMPNaFCysIClEDTANH4+PCMBEGTA... |
No evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_101402
Most Similar Human Ortholog: H0Y9M0
TM-align score: 0.88 | RMSD: 1.91
Seq Identity: 0.37 | Length: 196 / 2657
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000145725 | diphosphoinositol pentakisphosphate kinase 2 |
| ENSG00000168781 | diphosphoinositol pentakisphosphate kinase 1 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 28 | 104 | 52 | 136 |
| disruptive | 99 | 249 | 123 | 323 |
| missense | 49 | 170 | 104 | 253 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 40 | 220 | 83 | 136 |
| disruptive | 152 | 504 | 216 | 562 |
| missense | 73 | 352 | 173 | 386 |
PlasmoDB Total SNPs: 298
Non-coding: 17 | Synonymous: 170 | Nonsynonymous: 109 | Stop Codon: 2
Protein Length: 2657 | Molecular Weight (kDa): 306.807
UniProt ID(s): Q8ILG1
PDB ID(s): None
Isoelectric Point: 6.98
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000560 | Histidine phosphatase superfamily, clade-2 |
| InterPro | IPR029033 | Histidine phosphatase superfamily |
| InterPro | IPR033379 | Histidine acid phosphatase active site |
| InterPro | IPR037446 | Histidine acid phosphatase, VIP1 family |
| InterPro | IPR040557 | VIP1, N-terminal |
| PFam | PF00328 | Histidine phosphatase superfamily, clade-2 |
| PFam | PF18086 | VIP1, N-terminal |
| Superfamily | SSF53254 | Histidine phosphatase superfamily |
| Superfamily | SSF56059 |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |