About Gene List

PF3D7_1430500

Genome location: Pf3D7_14_v3:1,205,088..1,206,416(+)

Genome classification: Core

Function and Localization

Product Description: conserved Plasmodium protein, unknown function

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite not expressed N/A N/A
Ring not expressed 0.01 0.99
Trophozoite not expressed 0.02 0.99
Schizont not expressed 0.04 0.97
Gametocyte possibly expressed 0.15 0.91

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1430500

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -2.235 | #Insertions: 1

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILF9

"Best" AlphaFill ligand hit: 1CY (1-(4-chlorophenyl)-6,6-dimethyl-1,6-dihydro-1,3,5-triazine-2,4-diamine, Local RMSD=4.55) with 3UM6 (Global RMSD=19.76)

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532975

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 3 22 7 27
disruptive 3 27 24 46
missense 2 26 24 42

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 10 34 13 27
disruptive 8 61 38 69
missense 4 56 36 59

PlasmoDB Total SNPs: 14

Non-coding: 0 | Synonymous: 13 | Nonsynonymous: 1 | Stop Codon: 0

Protein Information

Protein Length: 442 | Molecular Weight (kDa): 52.788

UniProt ID(s): Q8ILF9

PDB ID(s): None

Isoelectric Point: 5.26

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097