Genome location: Pf3D7_14_v3:1,213,677..1,215,778(+)
Genome classification: Core
Product Description: PhIL1 interacting protein PIP3
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0071944 | cell periphery |
| Component | GO:0070258 | inner membrane pellicle complex |
| Function | GO:0005515 | protein binding |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | not expressed | N/A | N/A |
| Ring | not expressed | 0.00 | 1.00 |
| Trophozoite | possibly expressed | 0.01 | 1.00 |
| Schizont | not expressed | 0.02 | 0.99 |
| Gametocyte | expressed | 0.76 | 0.59 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1430800
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS *tentative
MIS: 1 | MFS: 0 | #Insertions: 0
PlasmoGEM Phenotype: Dispensable (Pb ortholog: PBANKA_1013900)
RMgmDB ABS Phenotype: Different from wild type (Pb ortholog: PBANKA_1013900)
Modification: Disrupted | RMgm-2779
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILF6
"Best" AlphaFill ligand hit: No AlphaFill hits
No associated EC numbersNo evidence of orthology to BindingDB entries
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 0 | 9 | 9 | 11 |
| disruptive | 2 | 6 | 3 | 8 |
| missense | 2 | 6 | 3 | 5 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 2 | 25 | 9 | 15 |
| disruptive | 6 | 23 | 14 | 59 |
| missense | 5 | 18 | 11 | 41 |
PlasmoDB Total SNPs: 108
Non-coding: 99 | Synonymous: 8 | Nonsynonymous: 1 | Stop Codon: 0
Protein Length: 265 | Molecular Weight (kDa): 30.466
UniProt ID(s): Q8ILF6
PDB ID(s): None
Isoelectric Point: 8.39
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | N/A | N/A |
| PFam | N/A | N/A |
| Superfamily | N/A | N/A |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 28428983 | Rapid inducible protein displacement in Plasmodiumin vivo and in vitro usingknocksideways technology. | Hughes KR, Waters AP | 10.12688/wellcomeopenres.11005.1 |
| 28985225 | Disrupting assembly of the inner membrane complex blocks Plasmodium falciparumsexual stage development. | Parkyn Schneider M, Liu B, ..., Dixon MWA | 10.1371/journal.ppat.1006659 |