Product Description: ribosomal protein L17, mitochondrial, putative
SignalP Peptide: N/A
# Transmembrane Domains: 0
EC Numbers: None
Curated GO (PlasmoDB):
| Type | GO Term | Name |
|---|---|---|
| Component | GO:0015934 | large ribosomal subunit |
| Component | GO:0005739 | mitochondrion |
| Component | GO:0000315 | organellar large ribosomal subunit |
| Function | GO:0003735 | structural constituent of ribosome |
| Process | GO:0006412 | translation |
Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):
| Stage | LR class | MCA mean | MCA prop. zeros |
|---|---|---|---|
| Sporozoite | expressed | N/A | N/A |
| Ring | possibly expressed | 0.03 | 0.99 |
| Trophozoite | expressed | 0.23 | 0.85 |
| Schizont | expressed | 0.03 | 0.98 |
| Gametocyte | expressed | 0.30 | 0.82 |
More info:
Old (Pf3D7v3) Gene ID: PF3D7_1431000
Resistome Missense Mutations: None
Resistome Compounds with Missense Mutations: None
Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)
Zhang Phenotype: Non - Mutable in CDS
MIS: 0.194 | MFS: -3.203 | #Insertions: 0
PlasmoGEM Phenotype: Essential (Pb ortholog: PBANKA_1237200)
RMgmDB ABS Phenotype: N/A
More info: PhenoPlasm Link
AlphaFill Uniprot ID: Q8ILF5
"Best" AlphaFill ligand hit: SPD (n-(2-amino-propyl)-1,4-diaminobutane, Local RMSD=0.28) with 7A18 (Global RMSD=1.46)
No associated EC numbersNo evidence of orthology to BindingDB entries
Ortholog Group (OrthoMCL): OG6_100929
Most Similar Human Ortholog: Q9NRX2
TM-align score: 0.64 | RMSD: 2.45
Seq Identity: 0.26 | Length: 126 / 257
All Human Orthologs (OrthoMCL):
| Gene ID | Description |
|---|---|
| ENSG00000158042 | mitochondrial ribosomal protein L17 |
MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:
Homozygous genotype calls only
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 3 | 13 | 3 | 19 |
| disruptive | 1 | 9 | 9 | 26 |
| missense | 1 | 9 | 9 | 22 |
Any inclusion in genotype call
| variant type | common | rare | doubleton | singleton |
|---|---|---|---|---|
| synonymous | 6 | 30 | 7 | 15 |
| disruptive | 6 | 30 | 18 | 63 |
| missense | 2 | 27 | 14 | 48 |
PlasmoDB Total SNPs: 107
Non-coding: 97 | Synonymous: 7 | Nonsynonymous: 3 | Stop Codon: 0
Protein Length: 257 | Molecular Weight (kDa): 31.147
UniProt ID(s): Q8ILF5
PDB ID(s): None
Isoelectric Point: 10.3
Protein Domain Annotations:
| Source | Family ID | Description |
|---|---|---|
| InterPro | IPR000456 | Ribosomal protein L17 |
| InterPro | IPR036373 | Ribosomal protein L17 superfamily |
| PFam | PF01196 | Ribosomal protein L17 |
| Superfamily | SSF64263 | Ribosomal protein L17 superfamily |
| PMID | Title | Authors | DOI/Link |
|---|---|---|---|
| 12368864 | Genome sequence of the human malaria parasite Plasmodium falciparum. | Gardner MJ, Hall N, ..., Barrell B | 10.1038/nature01097 |
| 16267556 | A protein interaction network of the malaria parasite Plasmodium falciparum. | LaCount DJ, Vignali M, ..., Hughes RE | 10.1038/nature04104 |
| 34494883 | A Prioritized and Validated Resource of Mitochondrial Proteins in PlasmodiumIdentifies Unique Biology. | van Esveld SL, Meerstein-Kessel L, ..., Huynen MA | 10.1128/mSphere.00614-21 |