About Gene List

PF3D7_1431100 (PIP2)

Genome location: Pf3D7_14_v3:1,220,473..1,223,467(+)

Genome classification: Core

Function and Localization

Product Description: PhIL1 interacting protein PIP2

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB):

Type GO Term Name
Component GO:0070258 inner membrane pellicle complex
Function GO:0005515 protein binding

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage LR class MCA mean MCA prop. zeros
Sporozoite expressed N/A N/A
Ring possibly expressed 0.04 0.98
Trophozoite not expressed 0.03 0.98
Schizont not expressed 0.04 0.97
Gametocyte expressed 1.73 0.36

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1431100

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Non - Mutable in CDS

MIS: 0.213 | MFS: -2.852 | #Insertions: 0

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILF4

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_532873

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type common rare doubleton singleton
synonymous 2 19 7 30
disruptive 6 10 9 22
missense 6 10 9 22

Any inclusion in genotype call

variant type common rare doubleton singleton
synonymous 9 27 17 39
disruptive 8 27 29 69
missense 8 23 26 53

PlasmoDB Total SNPs: 184

Non-coding: 166 | Synonymous: 11 | Nonsynonymous: 7 | Stop Codon: 0

Protein Information

Protein Length: 347 | Molecular Weight (kDa): 40.748

UniProt ID(s): Q03622, Q8ILF4

PDB ID(s): None

Isoelectric Point: 4.93

Protein Domain Annotations:

Source Family ID Description
InterPro N/A N/A
PFam N/A N/A
Superfamily N/A N/A

Associated Publications

PMID Title Authors DOI/Link
12368864 Genome sequence of the human malaria parasite Plasmodium falciparum. Gardner MJ, Hall N, ..., Barrell B 10.1038/nature01097
28985225 Disrupting assembly of the inner membrane complex blocks Plasmodium falciparumsexual stage development. Parkyn Schneider M, Liu B, ..., Dixon MWA 10.1371/journal.ppat.1006659