PF3D7_1431200

Genome location: Pf3D7_14_v3:1,223,443..1,229,071(-)

Genome classification: Core

Function and Localization

Product Description: OST-HTH associated domain protein, putative

SignalP Peptide: N/A

# Transmembrane Domains: 0

EC Numbers: None

Curated GO (PlasmoDB): None

Expression by stage (LR - Le Roch et al., and MCA - Malaria Cell Atlas):

Stage	LR class	MCA mean	MCA prop. zeros
Sporozoite	not expressed	N/A	N/A
Ring	possibly expressed	1.39	0.42
Trophozoite	not expressed	0.52	0.71
Schizont	possibly expressed	0.30	0.82
Gametocyte	not expressed	0.63	0.65

More info:

Resistome Mutations

Old (Pf3D7v3) Gene ID: PF3D7_1431200

Resistome Missense Mutations: None

Resistome Compounds with Missense Mutations: None

Resistome # Samples with Disruptive Mutations: 0 (0 missense, 0 "interesting" missense)

Essentiality (ABS)

Zhang Phenotype: Mutable in CDS

MIS: 1 | MFS: -0.994 | #Insertions: 13

PlasmoGEM Phenotype: N/A

RMgmDB ABS Phenotype: N/A

More info: PhenoPlasm Link

Binding Evidence

AlphaFill Uniprot ID: Q8ILF3

"Best" AlphaFill ligand hit: No AlphaFill hits

No associated EC numbers

No evidence of orthology to BindingDB entries

Orthology Information

Ortholog Group (OrthoMCL): OG6_146165

No human ortholog(s)

Genetic Variation

MalariaGEN Pf7 (worldwide samples) # unique SNV/indels:

Homozygous genotype calls only

variant type	common	rare	doubleton	singleton
synonymous	14	45	34	84
disruptive	108	233	136	293
missense	54	151	90	221

Any inclusion in genotype call

variant type	common	rare	doubleton	singleton
synonymous	24	100	52	90
disruptive	201	525	197	420
missense	93	329	144	242

PlasmoDB Total SNPs: 352

Non-coding: 151 | Synonymous: 87 | Nonsynonymous: 114 | Stop Codon: 0

Protein Information

Protein Length: 1225 | Molecular Weight (kDa): 146.488

UniProt ID(s): Q8ILF3

PDB ID(s): None

Isoelectric Point: 9.57

Protein Domain Annotations:

Source	Family ID	Description
InterPro	IPR025677	OST-HTH associated domain
PFam	PF14418	OST-HTH associated domain
Superfamily	N/A	N/A